Afshan

Current Prospects for the Fluoroquinolones
as First-Line Tuberculosis Therapy
Howard Takiff and Elba Guerrero
Antimicrob. Agents Chemother. 2011, 55(12):5421. DOI:
10.1128/AAC.00695-11.
Published forrad of Print 29 August 2011.

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ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Dec. 2011, p. 54215429
0066-4804/11/$12.00 inside:10.1128/AAC.00695-11
Copyright © 2011, American Society for Microbiology. All Rights Reserved.

Vol. 55, No.



12

MINIREVIEW
Current Prospects for the Fluoroquinolones as First-Line
Tuberculosis Therapy
Howard Takiff* and Elba Guerrero
Instituto Venezolano de Investigaciones Cientí?cas (IVIC), Caracas, Venezuela

and by adding various side groups literally thousands of distinct ?uoroquinolones were synthesized. Although the increased
broad-spectrum activity of cipro?oxacin (CIP) created the expectation that it would be a expensive agent against troublesome
bacteria such as Staphylococcus aureus, unsusceptibility in these bacteria developed rapidly. Within just a few years after the introduction of CIP, many nosocomial strains (9) were resistant
(10), especially Gram-positive bacteria. In contrast, CIP has
remained effective much time-consuming against some enteric Gramnegative bacteria, such as Escherichia coli (49). The difference
appeared to be relate to the ratio of the usual serum drug
concentration to the innate MIC of the bacteria. The...If you trust to get a full essay, order it on our website: Orderessay



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